- Nagasaki Prefecture has approximately 4,100km of coastline, ranking second in Japan after Hokkaido, yet its area is less than one-twentieth.
- Not a single point within the prefecture exists more than 15km from the sea.
- Japan's first national park 'Unzen-Amakusa National Park' spans Nagasaki and Kumamoto, with Unzen hot springs famous for jigoku (hell) tours.
- The prefectural flower Unzen Azalea (Miyama Kirishima) colors Mt. Unzen pink in May.
- Shimabara hand-pulled somen noodles have a 370-year history, with Japan's largest flowing somen events held.
- The roadside station 'Matsuura Sea Hometown Museum' with real whale skeletons declared itself the Holy Land of Aji Fry.
- Sasebo Burger is a local gourmet based on US Navy recipes, with sizes commonly exceeding 15cm diameter.
- Only Nagasaki City has streetcars within the prefecture, with a flat fare of 150 yen among the cheapest in Japan.
- The Goto Islands have Japan's highest church density, with small churches built in each settlement.
- Cross the Tsushima Strait to reach Busan, Korea about 50km away, 3 hours by Beetle high-speed ferry.
- Ganbaranba is Nagasaki dialect meaning 'let's do our best,' used as a cheer for national athletic meets and prefectural exercises.
- Nagasaki Airport opened in 1975 as the world's first full-scale offshore airport.
- Osezaki Lighthouse, selected as one of the 100 best sunsets, stands as a white beacon on cliffs at the westernmost point of the Goto Islands.
- World Cultural Heritage Former Glover Residence is Japan's oldest wooden Western-style house, also known as a site connected to Sakamoto Ryoma.
- The prefecture's only shinkansen 'Nishi-Kyushu Shinkansen Kamome' opened in 2022, connecting Nagasaki-Takeo Onsen in as fast as 30 minutes.