- Dogo Onsen, one of Japan's three ancient hot springs, is said to have been bathed in by Prince Shotoku and Natsume Soseki.
- Shimanami Kaido is popular as the world's first cycling road with expressway access spanning sea straits.
- Uwa Sea's farmed red sea bream production ranks first in Japan and is designated as the prefectural fish.
- Two of Japan's 12 original castles (Matsuyama Castle and Uwajima Castle) exist within the prefecture.
- The official mascot 'Mikyan' is modeled after mikan oranges and dogs.
- Naked barley production ranks first nationally, with developed barley miso culture.
- Mount Ishizuchi stands at 1,982m. It's a sacred mountain for mountain worship with thriving Shugendo practices.
- Dogo Onsen Honkan is a National Important Cultural Property, said to be one of the bathhouse models in Studio Ghibli's 'Spirited Away.'
- Imabari Towel is a world-renowned brand for excellent absorbency and safety standards.
- The blue-eyed charm 'Iyo Ittobori Hime Daruma' is a good luck item for safe childbirth.
- At Niihama Taiko Festival, 150 people carry drums weighing about 3 tons and standing approximately 5.5m tall.
- Multiple tourist facilities feature taps dispensing mikan orange juice.
- The prefecture name romanization 'EHIME' is often read abroad as 'E-hi-me Prefecture?'
- 26 of the 88 temples of the Shikoku Pilgrimage are located within the prefecture.
- Chuhachi Ninomiya, who devised Japan's first powered aircraft, was from Uwajima.